A highly efficient synthesis of the hemibrevetoxin B ring system.
نویسندگان
چکیده
[reaction: see text] This Letter describes the synthesis of the hemibrevetoxin B tetracyclic ring system in 14 linear transformations from the Danishefsky-Kitahara diene.
منابع مشابه
C-glycosides to fused polycyclic ethers. A formal synthesis of (+/-)-hemibrevetoxin B.
This paper describes a formal total synthesis of the marine ladder toxin hemibrevetoxin B from Danishefsky's dienes. This approach couples the generation of C-glycosides from cyclic enol ethers with metathesis or acid-mediated annulation reactions. The result is a highly efficient synthesis of the tetracyclic ring system of hemibrevetoxin B.
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ورودعنوان ژورنال:
- Organic letters
دوره 2 2 شماره
صفحات -
تاریخ انتشار 2000